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It is well known that
2024-04-08
It is well known that the thymus plays an important function in the complex pathogenesis and perpetuation of MG. We compared resistin levels between patients with MG with or without thymoma and found that those with thymoma had higher levels than those without thymoma. It has been previously recogni
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The hypothalamic pituitary adrenal HPA axis
2024-04-08
The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine system that is central to regulating responses to stress (Palazidou, 2012). In older persons, a high dysfunction of the HPA axis is observed (Otte et al., 2005) which may be enhanced by stimulatory effects of genes involved in the axi
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It has been reported that
2024-04-08
It has been reported that leukotrienes and their receptors, e.g. the cysteinyl leukotriene receptor 1 (CysLT1) may promote abscisic acid injury (Ding et al., 2007) and that increased 5-LOX expression and activity lead to production of brain-toxic molecules (Khan et al., 2010). However, differential
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These PrPIF are detected in untreated brain
2024-04-07
These PrPIF are detected in untreated DBU receptor extracts but are consistently enriched following proteinase K (PK) treatment. The biochemical characterization of pathologic PrP has been carried out in most hereditary PrP cerebral amyloidosis associated with PrP mutations and the biochemical PrP p
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MSG model is well characterized and widely used
2024-04-07
MSG model is well characterized and widely used because it is not influenced by dietary components and because it mimics a lesion in the arcuate nucleus and lateral hypothalamus that can occur in chronic obese patients (Moraes et al., 2009, Purkayasta and Cai, 2013). High fat fed diet is amongst the
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br LO synaptic integrity and memory Interestingly several gr
2024-04-07
12/15LO, synaptic integrity, and memory Interestingly, several groups have found that 12/15LO directly modulates synaptic function. Normandin and colleagues reported that pharmacological inhibition of 12/15LO modulates rat hippocampal long-term depression (LTD), a process by which neuronal synapt
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br Serine glycine and one carbon metabolism
2024-04-07
Serine/glycine and one-carbon metabolism Altered serine metabolism in tumors was noted nearly half a century ago, and elevated flux through the de novo serine synthesis pathway (SSP) is a common phenomenon in cancer Cy3.5 NHS ester (non-sulfonated) [43]. The SSP branches from glycolysis at the po
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A disfun o cognitiva p s operat ria
2024-04-07
A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma beta adrenergic receptors disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas permanece uma ques
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Introduction A defining feature of cancer cells is
2024-04-07
Introduction A defining feature of cancer cells is disruption of the normal controls of the cell cycle; a tumor suppressor or inhibitor may act by restricting progression of the cell cycle. P27 (also known as cyclin-dependent kinase inhibitor 1B, P27, or Kip1) is a putative cell-cycle inhibitor pro
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Liver plays a pivotal role in metabolism of
2024-04-07
Liver plays a pivotal role in metabolism of xenobiotic compounds, such as environmental contaminants and drugs. Some of these compounds generate hepatic damage and impair its function. It was well-known that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could induce pathological changes in mouse and ra
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The cytoplasmic domain of muscle AChR is
2024-04-03
The cytoplasmic domain of muscle AChR is not accessible to nop receptor in vivo. Theoretically, therapy with the cytoplasmic domains should be safe. Safety is demonstrated by the facts that: (1) rats repeatedly immunized with the cytoplasmic domains in TiterMax adjuvant do not develop EAMG, although
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Herein we disclose novel dihydropyrano c pyrazoles that inhi
2024-04-03
Herein, we disclose novel 2,4-dihydropyrano[2,3-c]pyrazoles that inhibit human ATX (hATX). Our results demonstrate and further support previous findings showing that a desired biological action can be achieved without targeting the catalytic site of the enzyme. Moreover, this study validated hen egg
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On the other hand there were only
2024-04-03
On the other hand, there were only a few cases that expressed DA2R in our study. Additionally, in the cases whose ACTH-secreting pituitary adenomas expressed DA2R, the ratio of positive staining A-71623 was very low. This suggests that dopamine agonists may be less effective in canine Cushing's dis
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To better illustrate the involved neuronal postganglionic pa
2024-04-03
To better illustrate the involved neuronal postganglionic pathways, central apelin-13 injection was performed in rats received peripheral preadministration of NOS inhibitor L-NAME, sympatholytic agent guanethidine and/or muscarinic receptor agonist bethanechol. Compared with the rats received vehicl
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Later on Wayner Burton Ingold Barclay
2024-04-03
Later on, Wayner, Burton, Ingold, Barclay, and Locke (1987) modified the method by using lipid to examine the ability of an antioxidant d-biotin protect against lipid peroxidation generated by azo-compound. It was later improved using β-phycoerythrin (β-PE) as a fluorescent probe, and the ability o
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