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molarity calc Toxoplasma gondii is an exceptionally tractabl
2022-05-13
Toxoplasma gondii is an exceptionally tractable apicomplexan parasite that expresses a limited yet representative subset of apicomplexan cyclase orthologs, making it an ideal model for investigating cyclic nucleotide signaling in Apicomplexa. Of the five putative nucleotide cyclases, only TgACα1 and
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Our observations with RBC in human platelets
2022-05-13
Our observations with RBC8 in human platelets suggested a more wide-ranging role for Rals in platelet function compared to our observations in Ral deficient mouse platelets. Using lumi-aggregometry, 10 μM RBC8 significantly reduced platelet aggregation and ATP secretion responses in both WT and DKO
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br Rho family GTPases are molecular switches
2022-05-13
Rho-family GTPases are molecular switches; most which cycle from an ‘on’ GTP bound state to an ‘off’ GDP bound state, driven by GEFs (guanine nucleotide exchange factors) and GAPs (GTPase-activating proteins) respectively. Association with lipid membranes through a lipid (farnesyl or geranylgerany
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In this study we also investigated the role of GST
2022-05-13
In this study, we also investigated the role of GST Dehydrocostus Lactone mg in relation to ASD. In univariable analyses, where the role of each GST gene (i.e., GSTM1, GSTT1, GSTP1) was individually assessed, we did not observe any significant associations between the GST genotypes and ASD. In cont
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The crystal structures of plant class
2022-05-13
The crystal structures of plant class ADH3/GSNOR from Arabidopsis thaliana (AtGSNOR) and Solanum lycopersicum cv. Amateur (SlGSNOR) with bound substrates and cofactors revealed important differences between plant and human enzyme, namely within the substrate-binding pocket. GSNOR are unusually homod
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In breeding season small mammals increase dispersal and soci
2022-05-13
In breeding season, small mammals increase dispersal and social communication to maximize their opportunity to mate. In the present study, we found that gerbils in April showed more locomotion and exploratory behavior in the open field test. Moreover, subadult gerbils in April and July were more lik
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br Materials and methods br Results br Conclusions We develo
2022-05-13
Materials and methods Results Conclusions We developed a glutamate biosensor with chitosan as a matrix for the immobilization of the enzyme glutamate oxidase on the surface of a platinum electrode. Our miniaturized biosensor of 50 µm in diameter can be applied for monitoring glutamate in vi
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In the present study we characterized the expression
2022-05-13
In the present study, we characterized the expression of glucose transporters in the developing and adult mouse lens and showed that GLUT1 is the primary transporter expressed in the lens epithelium. We found that mice with a homozygous deletion of Slc2a1 from the lens epithelium developed cataracts
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Transient forebrain ischemia in rodents induces
2022-05-13
Transient forebrain ischemia in rodents induces a reduction in expression of mRNA encoding the AMPA receptor subunit GluR265, 66, 67, 68, 69 (Fig. 3). gluR2 mRNA expression is markedly reduced in the CA1 region (the marizomib region most vulnerable to ischemia-induced damage), but not in the CA3 re
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In agreement with the results obtained from GluR A
2022-05-13
In agreement with the results obtained from GluR-A−/− mice, mice in which the NR1 subunit of the NMDA receptor has been selectively deleted from the CA3 subfield of the hippocampus displayed normal acquisition of the standard reference memory version of the watermaze task (Nakazawa et al., 2002), bu
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br Discussion According to the generally accepted notion whi
2022-05-13
Discussion According to the generally accepted notion which originated from the study of ATP-depleted Ac-IETD-pNA australia the changes in Ca2+ homeostasis induced by ATP depletion and leading to the activation of the Gárdos effect are due to the inhibition of Ca2+ pumping, and the subsequent ent
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Moreover after the initial bleaching of the fluorescent
2022-05-13
Moreover, after the initial bleaching of the fluorescent molecules in the targeted cell exposed to laser illumination, the neighboring reservoir Oltipraz are expected to give in return new fluorescent ones if the cells are coupled together by gap junction channels. This supposes that the level of fl
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br Results The RAS MEK ERK pathway
2022-05-12
Results The RAS/MEK/ERK pathway is a potential target of FGFR signaling. Indicative for its activation is the presence of double phosphorylated (activated) ERK (dpERK), which is generated in a series of phosphorylation events downstream of FGFR (op. cit. (Lemmon and Schlessinger, 2010)). Followin
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In Apicomplexan parasites such as Toxoplasma gondii isopreno
2022-05-12
In Apicomplexan parasites such as Toxoplasma gondii isoprenoids are biosynthesized through the DOXP/MEP pathway as illustrated in Scheme 2. In addition, T. gondii possesses a bifunctional FPPS/GGPPS (TgFPPS) that is able to catalyze the formation of both FPP and GGPP.5, 6 The FPPS gene appears to be
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Compound a substituted phenyl H pyrano d d dipyrimidine
2022-05-12
Compound 6, a 5-(4-substituted-phenyl)-5H-pyrano[2,3-d:-6,5-d′]dipyrimidine derivative was invented previously to have significant efficacy to inhibit HIV integrase enzyme with 0.9 ± 0.4 μM of IC50 against 3′-processing and 16.1 ± 10.7 μM of IC50 against strand transfer suppression. The compound ind
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