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Experiments show that CSD propagation can be
2022-03-29
Experiments show that CSD propagation can be slowed or interrupted by pre-existing lesions or areas of high astrocytic density (Chen et al., 2006), and reduced expression of astrocytic gap junctions significantly increases the size of ischemic infarcts (Nakase et al., 2003). By decreasing the gap ju
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The role of GJs in liver fibrogenesis was
2022-03-29
The role of GJs in liver fibrogenesis was studied recently. Studies showed a significant decrease in liver fibrosis in Cx32 knockout mice compared to wild-type mice. Although the mechanism underlying this protective effect of Cx32 deletion is not clear, reduced oxidative stress was suggested as a po
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It has also been demonstrated that PS is ubiquitinated by
2022-03-29
It has also been demonstrated that PS1 is ubiquitinated by Caenorhabditis elegans SEL-10 [52], Fbw7 the mammalian homologue of SEL-10 [38], and more recently by tumour necrosis factor n-acetyl-l-cysteine associated factor 6 (TRAF6), which facilitates Lysine-63 (K63)-linked polyubiquitination of PS1
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br Materials and methods br Results Bgal from
2022-03-29
Materials and methods Results Bgal from Alteromonas sp. ML117 had an open reading frame of 3126 bp encoding 1042 amino ciprofloxacin residues with a predicted mass of 120 kDa and a theoretical pI (isoelectric point) of 5.44. The recombinant Bgal contained a His tag, as well as other additiona
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Similarly spectrophotometric titrations were carried out und
2022-03-29
Similarly, spectrophotometric titrations were carried out under conditions identical to those used for the fluorescence titrations. exhibited a predominant H-Lys(Ac)-OH.HCl band at around 493 nm. The titrations with all G-quadruplex DNAs resulted in a hypochromic effect along with a bathochromic
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G quadruplex structures can be resolved by
2022-03-29
G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer Wortmannin [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and discovered that
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Statins are recognized by their nephroprotective
2022-03-29
Statins are recognized by their nephroprotective effect (Chmielewski et al., 2002). The hepato- and nephroprotective effects of silymarin are also well studied (Alqasoumi, 2014, Mohamed et al., 2018). Several studies documented increasing Cy7 NHS ester of FXR by statins (Byun et al., 2014& (Lu et a
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So what makes a FFAR agonist different and interesting
2022-03-29
So what makes a FFAR1 agonist different and interesting? As shown in the , the cellular mechanism is different from those of present insulin-releasing pharmacotherapies—namely the secretion initiators (sulphonylureas and meglitinides) and the incretin-based secretion potentiators (glucagon-like pept
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Although angiogenesis is crucial for cerebral ischemic rehab
2022-03-28
Although angiogenesis is crucial for cerebral ischemic rehabilitation, the mechanism underlying NGF promotion of angiogenesis is not clear. Previous studies showed that angiogenesis can be promoted by FAK, in a breast cancer model [19]. Recent studies showed that FAK phosphorylation participated in
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br Place in Therapy In
2022-03-28
Place in Therapy In the case of minor bleeding, the anticoagulant effects of all FXa inhibitors except betrixaban, which has a longer half-life, will diminish within 24-48 hours of discontinuation of the drug provided the patient has normal renal function. In these cases stopping the FXa inhibito
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One PKC target that controls cortical actin structure
2022-03-28
One PKC target that controls cortical 6-Chloromelatonin structure is a well-known actin crosslinking protein, myristoylated alanine-rich C-kinase substrate (MARCKS). MARCKS cross-links actin and binds PIP2 and this binding activity is regulated by PKC phosphorylation [82]. Activation of PKC releases
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Relative to the impact of moderate
2022-03-28
Relative to the impact of moderate PAE on markers of histaminergic neurotransmission, there were four salient observations from the studies reported here. First, it does not appear that moderate PAE affects the number of HDC-positive neurons in the tuberomammillary nucleus of the ventral hypothalamu
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The H R antagonist JNJ developed
2022-03-28
The H3R antagonist JNJ-17216498, developed by Johnson & Johnson, has entered clinical trial studies, but no information regarding its structure has been publicized to date. A phase II study of JNJ-17216498 monotherapy has been completed for patients with narcolepsy, but the results are not publicall
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Newly identified evidence has put
2022-03-28
Newly identified evidence has put immune checkpoint inhibitors into the spotlight. However, even though they have been reported to achieve optimistic outcomes [67], there is still a provocative question about their limitations [68]. The solid evidence above has provided us with translational values
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A number of studies have reported
2022-03-28
A number of studies have reported that lncRNA may function as sponge to interact with miRNAs at posttranscriptional level, thereby regulating miRNA targeted genes (Tang et al., 2015, Han et al., 2015). For example, lncRNA Malat1 induces autophagy by regulating ULK2 via sponging miR-26b (Li et al., 2
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