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The lack of inhibition of K efflux in normal
2022-02-23
The lack of inhibition of K+ efflux in normal red cells reported by Fathallah et al. [16] was attributed by the authors to a lower level (about half) of membrane PKCα activity. In our experiments, single channel recording probably overcame this difficulty because of its molecular detection level. O
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br Conclusions There are a
2022-02-23
Conclusions There are a number of factors that affect the transit of solutes through gap junction channels. Fig. 4 provides a simplified illustration of those factors. First is the cytoplasmic vestibule through which all permeable solutes must pass to gain access to the pore. In an equivalent cir
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Gap junction intercellular communication GJIC facilitates
2022-02-23
Gap junction intercellular communication (GJIC) facilitates the exchange of ions, metabolites, Ca2+, inositol phosphates, and/or cyclic nucleotides of up to 1.8 kD in size between matrix metalloproteinase through contact-dependent mechanisms [3,4]. Oocyte growth and development (as depicted in Fig.
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Based on the collective experience to date it is likely
2022-02-23
Based on the collective experience to date, it is likely that a much more comprehensive assessment of GSI selectivity for inhibition of multiple substrates, as well as biomarkers to track inhibition of non-APP substrates in vivo will be needed to support future efforts to develop substrate selective
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Comparison of dlGALRs deduced amino acid sequences
2022-02-23
Comparison of dlGALRs deduced amino N-3-oxo-dodecanoyl-L-Homoserine lactone mg sequences with that of human GALRs demonstrate that the GALR1 ortholog sequences have diverged less than those of GALR2. Since often duplicate genes undergo divergent evolution through sub-functionalization, loss or gain
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br Galanin in depression A major impediment in
2022-02-23
Galanin in depression A major impediment in depression research is the lack of validated animals´ models. Animals not only lack consciousness of self, self-reflection and consideration of others but also hallmarks of the disorder such as depressed mood, low self-esteem or suicidal intent are hard
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Michiel S van der Heijden had
2022-02-23
Michiel S. van der Heijden had full access to all nitric oxide data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Wang, Sustic, de Oliveira, van den Heuvel, Bernards, van der Heijden. Wang, Sustic, de Oliveira, van de Ven. Wang, Sus
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br Rationale The present study was
2022-02-23
Rationale The present study was motivated to get further insight into the molecular recognition processes of 2-alkyl(amino)ethyl-1,1-bisphosphonates taking compounds 12–14 as reference structures. We have recently demonstrated that TcFPPS inhibitors 12 and 13 bind to the allylic site of the enzym
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br FAAH mediation of fear and extinction
2022-02-23
FAAH mediation of fear and extinction In addition to being a major target and modulator of stress, the BLA is a critical node within the neural circuitry subserving learned fear behaviors. The BLA is activated during the formation, expression, and extinction of conditioned fear memories, and dama
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MicroRNAs miRNAs are endogenous small RNA
2022-02-23
MicroRNAs (miRNAs) are endogenous small RNA molecules 20–25 nucleotides in length; they regulate multiple genes by binding to target mRNAs, thereby controlling the stability and translation of protein coding mRNAs (Esteller, 2011, Guo et al., 2010). It has been established that 2602 synthesis of th
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br Application of TIRFM to visualizing exocytosis TIRFM was
2022-02-23
Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin Natural Product Library receptor (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such as ma
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Recent advances in imaging single protein mobility and organ
2022-02-23
Recent advances in imaging single protein mobility and organization in live organisms such as Drosophila larva motor nerve terminals have initiated this by providing a useful platform to investigate how the dynamic changes in the actomyosin network correlates with vesicle docking and fusion in vivo2
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Apoptosis is one of critical
2022-02-22
Apoptosis is one of critical toxic mechanisms of benzene metabolites. In this work, overexpression of HIF-1a could significantly reduce the increase in cell apoptosis caused by 40 μM BQ. At the meanwhile, anti-apoptotic protein Bcl-2 level was significantly elevated in HIF-1a overexpression cells t
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For further understanding of the
2022-02-22
For further understanding of the interaction between these inhibitors and proteins (BRafV600E and HDAC1) for guiding the SAR, compound 10e, the most potent compound of this series, was chosen as a representative for docking into the BRafV600E (PDB code: 1UWJ) and HDAC1 (PDB code: 1C3R), revealing ex
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Among the GSK inhibitors available in
2022-02-22
Among the GSK-3 inhibitors available in market, lithium is probably the only example and the oldest one. Some molecules, both natural and synthetic, such as maleimide derivatives, staurosporine (from the bacterium Streptomyces storosporeus), indole derivatives such as indirubin (used since long in t
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