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A phenylacetic acid derivative discovered in a
2021-04-07
A phenylacetic 17 aag derivative (), discovered in a high throughput screen for CRTH2, inhibited the binding of H-PGD to CRTH2 receptors on 293 cells with an IC of 0.010μM, and inhibited the binding of H-PGD to DP receptors with an IC of only 8.3μM (). Compound also inhibited CRTH2 mediated cell
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TMC120 sale br Involvement of p MAPK pathway The
2021-04-07
Involvement of p38 MAPK pathway The NF-κB signal transduction cascade is a major stress response signaling pathway for the COX-2 gene expression. In mice and humans, the COX-2 promoter has TMC120 sale for many transcription factors, including NF-κB in the 5′ region of the COX-2 gene [11], and the
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CD is a key co stimulation surface marker that
2021-04-07
CD28 is a key co-stimulation surface marker that can be detected in all peripheral T Vanoxerine in newborns, and the proportion of CD28bearing T cells reduces progressively with age [reviewed by (Fagnoni et al., 1996; Weng et al., 2009)]. Therefore, CD28nullCD8+ T cells are one of the most acknowle
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In summary synthetic routes with moderate to high yields hav
2021-04-07
In summary, synthetic routes with moderate to high yields have been developed to produce difluoro-dioxolo-benzoimidazol-benzamides including reference standards and , and -desmethylated precursors and , and carbon-11-labeled difluoro-dioxolo-benzoimidazol-benzamides target tracers [C] and [C]. The
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The absence of an observable
2021-04-07
The absence of an observable time dependence of kobs on inhibitor concentration for CGP 41251 3 with AChE and compounds 1, 3 and 4 with BuChE parallels a similar absence of time dependence for some related fluoro ketones with AChE. Nair et al. found that trifluoromethyl acetophenones with small met
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br Experimental br Results br Discussion
2021-04-07
Experimental Results Discussion In the last two decades, several studies have shown an important role for progestogens, and in particular ALLO, in the modulation of Schwann cell physiology, regulating several biochemical and functional parameters. The classical PR has been found both in rat
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Although information regarding the influence of PGE on
2021-04-06
Although information regarding the influence of PGE2 on cardiac fibroblast cell growth is sparse, the effect of PGE2 on other cell types has been studied extensively, particularly in cancer and cancer cell lines where COX-2 is over-expressed. Constitutive high levels of COX-2 expression have been no
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br Materials and methods br Results Overexpression of KLF in
2021-04-06
Materials and methods Results Overexpression of KLF2 increased the cell viability and reduced the LDH leakage rate and O2•− and ONOO− generation in H/R HUVEC model. To evaluate the effect of KLF2 on H/R HUVEC injury, KLF2 was overexpressed in HUVECs. Cell viability and extracellular LDH level
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Many studies have documented that enolase acts as a
2021-04-06
Many studies have documented that enolase acts as a plasminogen-binding protein and this interaction is involved in the tissue invasion and pathogenicity of the causative agents (Almeida et al., 2004; Avilan et al., 2000; Marcilla et al., 2007; Mundodi et al., 2008; Vanegas et al., 2007). Furthermor
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br Acknowledgments br Introduction br Endothelin receptors S
2021-04-06
Acknowledgments Introduction Endothelin receptors Shortly after the discovery of ET‐1, two types of seven transmembrane G protein‐coupled receptors were cloned called endothelin receptor A (ETA) (Arai et al., 1990) and ETB (Sakurai et al., 1990). The affinity of the ETA receptor for ET-3 is
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The expression of DDR receptor has
2021-04-06
The expression of DDR2 receptor has regulated by numerous types of factors depending upon the cell type. During the osteogenic differentiation, the transcription factorATF4 combined with CCAAT/enhancer binding site in the DDR2 promoter, which is responsible for induction of DDR2 transcription [24].
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Bcl functions as a transcription repressor via its N
2021-04-06
Bcl6 functions as a transcription repressor via its N-terminal BTB domain and middle “second repression,” or “RD2” domain (Chang et al., 1996, Seyfert et al., 1996). A loss of function of the BCL6 BTB domain markedly impairs survival and proliferation of mature GC GTP-Binding Protein Fragment, G alp
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It has been reported about the synthesis of
2021-04-06
It has been reported about the synthesis of benzyl bromide in our previous reports, as shown in , , The synthetic route of compounds – is depicted in , Briefly, the synthesis of pyrimidinedione derivatives was started from commercially available HC-030031 . After alkylation of material with 1-bromo-
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Addressing whether impaired activation of D
2021-04-06
Addressing whether impaired activation of D1 and D2 receptors regulates memory capacity is relevant for all human pathologies that lead to reduced activation of these X-Gal sale pathways, such as ageing [39], certain genetic polymorphisms [40] and neurodegenerative disorders. In this study, we have
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br Materials and methods br Results br Discussion
2021-04-06
Materials and methods Results Discussion Structural analysis of dnmt3 sequences of different ploidy fish cloned in this study showed high similarities to zebrafish sequences, which also contained a unique N-terminal motif and a calponin homology (CH) domain, a conserved proline-tryptophan-t
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