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br Results and discussions Fig depicts the
2020-08-06
Results and discussions Fig. 10 depicts the trajectory of a gun drill chip. As soon as the chip breaks away from the cutting edges (Fig. 10a), it is carried by the coolant towards the wall of the hole (Fig. 10b), resulted in the first collision (Fig. 10c). The chip is then rebounded from the wall
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There is no evidence for Complex
2020-08-06
There is no evidence for Complex I presence in the P. falciparum mitochondrial 4-ap transport chain, but bioinformatic analysis has identified the type II NADH dehydrogenase (PfNDH2) (Gardner et al. 2002). Analysis of the PfNDH2 gene indicates that the PfNDH2 protein is a single 52kDa monomer and p
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Although dasatinib does not distinguish DDR from DDR whose
2020-08-06
Although dasatinib does not distinguish DDR2 from DDR1 whose knockout mice were similarly refractory to bleomycin-induced lung fibrosis,, it is unlikely that the therapeutic effects of dasatinib treatment starting from 14 days after bleomycin in our model could equally benefit from its inhibition of
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Variability in response to antipsychotics can be influenced
2020-08-06
Variability in response to antipsychotics can be influenced by an array of factors, including age, sex, ethnicity, nutritional status, smoking, and alcohol use. There is strong evidence for the role of genetic variability in individual responses to antipsychotic therapy. Advances in pharmacogenetic
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Indeed some cancers may even
2020-08-06
Indeed, some cancers may even be defined by dysregulated cyclin and thus CDK activity: mantle cell lymphoma, an uncommon lymphoma of mature B cells, is defined by the presence of overexpressed cyclin D1, usually as a result of a translocation between chromosomes 11 and 14 with the net result that cy
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Introduction The COMT gene is located
2020-08-06
Introduction The COMT gene is located on chromosomal band 22q11.2, extends over 28 kb, contains six exons, and encodes for catechol-O-methyl-transferase (Weinshilboum and Raymond, 1977; Grossman et al., 1992; Lundström et al., 1995; Bearden et al., 2005). This enzyme plays a major role in regulati
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Rice husk the outer covering of rice grains is one
2020-08-06
Rice husk, the outer covering of rice grains, is one of the main agricultural residues which is obtained during the milling process. Application of rice husk as an energy source for Tenatoprazole power plants, rice mills and brick factories is increasing due to its high calorific power [13]. In thi
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Ethacrynic Acid In conclusion we have identified Ednra
2020-08-05
In conclusion, we have identified Ednra as a downstream direct target of Hoxa9 and Meis1. Upregulation of Ednra has a role in the progression of Hoxa9+Meis1-induced leukemia and targeting Ednra together with other chemotherapies may have therapeutic benefits for leukemia [30]. Ednra inhibitors in th
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br Abbreviations br Introduction br Collagen induced DDR act
2020-08-05
Abbreviations Introduction Collagen-induced DDR activation A key feature of DDRs is their ability to bind both fibrillar and non-fibrillar collagens (Shrivastava et al., 1997, Vogel et al., 1997). DDR1 and DDR2 recognize the GVMGVO (O, hydroxyproline) motif within fibrillar collagens I–III
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The nitro furan ylmethylene dioxo pyrazolidin yl benzoic
2020-08-05
The 4[4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic Zanamivir ethyl ester (hereafter PYR-41) and related pyrazones are cell-permeable UBE1 inhibitors identified in high-throughput screening of the UBE1–UBE2–UBE3 cascade, which selectively and irreversibly inhibits UBE1 activit
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br Subjects and methods Four
2020-08-05
Subjects and methods Four independent Caucasian PD patient–controls series from the US, Ireland, Norway and Poland were examined. The combined series provides a total sample size similar to the two previous studies, with 1037 PD patients and 1659 control subjects. The demographics for each indivi
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The proof of concept chemogenomic profiling experiments
2020-08-05
The proof of concept chemogenomic profiling experiments in P. falciparum (Fig. 3A) showed that the primary drug target can be revealed as a significant EC50 ratio. All antifolates were identified as DHFR-TS targeting drugs, despite the wide variation in antimalarial potency from the extremely potent
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Studies with CysLT receptor antagonists have always provided
2020-08-05
Studies with CysLT receptor antagonists have always provided a controversial picture on the role for cysteinyl-LTs in the development of ischemic damage and in cardiac dysfunction, with conclusions often contradicting each other. Indeed, recent evidence showed that montelukast, zafirlukast and pranl
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Another potential use for CDK inhibitors in CLL is in
2020-08-05
Another potential use for CDK inhibitors in CLL is in the context of lymphocytosis that has plateaued during treatment with a BCR pathway inhibitor. Although it has recently been shown that patients with prolonged lymphocytosis following achievement of PR with lymphocytosis (PR-L) do not fare more p
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br Phosphorylation of DNA PKcs Following induction of a DSB
2020-08-04
Phosphorylation of DNA-PKcs Following induction of a DSB, DNA-PKcs is phosphorylated on more than 40 sites including at a number of phosphorylation clusters (discussed sites outlined in Fig. 2) [78]. The best characterized DNA-PKcs phosphorylation cluster is the threonine 2609 (Thr2609) cluster.
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