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How ERR represses the ERR
2020-07-31
How ERRα represses the ERRγ-stimulated MHRE activity is unclear, nonetheless, we can rule out the competition for binding to the DNA since ERRα mutants deficient in DNA binding (p-box mut) retain the repression function, whereas the N-terminus containing the DNA binding domain lost the repression fu
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br Peroxygenases The complexities and limitations associated
2020-07-31
Peroxygenases The complexities and limitations associated with P450 systems have spurred research on alternative enzyme classes. Besides P450 monooxygenases, many other enzymes are known which catalyze selective oxyfunctionalizations of C–H bonds, including both heme-dependent enzymes and non-hem
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In addition the kidney is also capable
2020-07-31
In addition, the kidney is also capable of actively metabolizing many drugs, hormones and xenobiotics [4], [5], [6], [7]. Several compounds are known to be activated locally by renal biotransformation processes. For example, in male mice, chloroform, acetaminophen and 1,1-dichloroethene are bioactiv
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br Results br Discussion The Ube E group
2020-07-31
Results Discussion The Ube2E group of ubiquitin-conjugating enzymes, classified as the Class III E2s owing to their N-terminal extensions, is considered as “hub” E2s due to their capability of interacting with a large number of E3 ligases [26], [33]. The “E3 interactome” of these E2s is second
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Because the E enzyme directly recognizes
2020-07-31
Because the E2 enzyme directly recognizes a SCM, it can modify substrates in vitro at high enzyme concentrations as we illustrate in Fig. 1A. Hence, it is important to use a low E2 concentration in E3-dependent reactions that either show no or only marginal substrate modification by the E2 alone. At
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Psychrobacter arcticus is a gram negative bacterium discover
2020-07-31
Psychrobacter arcticus 273–4 is a gram-negative bacterium discovered in 20–30 thousand year old permafrost soil in Kolyma, Siberia [17]. P. arcticus 273-4 has been SR 3576 mg sequenced [18], grows at temperatures from −10 to 28 °C and has generation time of 3.5 days at temperatures below zero [[17]
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CD T cells respond to pathogens and tumors following T
2020-07-31
CD8+ T SC 79 respond to pathogens and tumors following T cell receptor (TCR) recognition of specific peptides presented by the major histocompatibility complex (MHC). TCR-activated cells secrete interleukin 2 (IL-2), which promotes expression of CD25, the IL-2 receptor α chain that forms the high-a
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br Conclusions In this paper we have
2020-07-31
Conclusions In this paper we have succeeded in what we fail in our previous report [5]. In this case we have been able to get an excellent correlation between the electronic densities obtained from a QTAIM study with the experimental data. It is important to note that through this study is possib
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Research using animal models has indicated a
2020-07-31
Research using animal models has indicated a critical role for the interaction between dopaminergic activity in the prefrontal cortex and striatum in set-shifting. Specifically, cognitive flexibility is impaired by a combination of decreased prefrontal dopamine (DA) and elevated striatal DA, while c
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The downregulation of HSP protein in response
2020-07-31
The downregulation of HSP27 protein in response to CK2 inhibition prompted us to hypothesize that these SR 11302 could be more sensitive to heat shock treatment, being HSP27 generally considered an important player in cell thermotolerance [29]. The contribution of HSP27 to thermotolerance has been
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br Materials and methods br Results
2020-07-30
Materials and methods Results Discussion A significant decrease in fluorescence was observed after the treatment of pure DNA with alkylating compounds. This decrease was characterized by a dose-response relationship. Mass spectrometry and additional fluorescence measurements ruled out the c
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In KSTD the FAD adopts an extended
2020-07-30
In Δ1-KSTD1, the FAD adopts an extended conformation with an almost planar isoalloxazine ring system, similar to what has been found in proteins belonging to the glutathione reductase family [125]. It fits in an elongated cavity in the FAD-binding domain. Its adenine end is in front of the parallel
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Instead of receptor interaction or GT activity we focused on
2020-07-30
Instead of receptor interaction or GT activity, we focused on the CPD and autoprocessing. The CPDs from the 2 toxins are highly homologous: each cysteine protease targets an intramolecular substrate and mediates InsP6-induced autoprocessing to release the GTD into host cytosol.40, 41 However, TcdB i
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The present review also summarizes the efforts that have bee
2020-07-30
The present review also summarizes the efforts that have been made to find new c-FMS inhibitors under clinical trial as given in the Table 1. These inhibitors may reduce the burdens of potency and side effects that have faced the scientists globally. ABT-869 41 was manufactured in Abbott laboratorie
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br Experimental procedures br Acknowledgement br Introductio
2020-07-30
Experimental procedures Acknowledgement Introduction The neurobiology of stress-related mood disorders and related anxiety disorders has been extensively studied over the last decades to develop new strategies and effective therapeutic approaches to psychiatric diseases (Catena-Dell’Osso e
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