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During recent years two primary types of
2020-05-15
During recent years, two primary types of models have been applied for calculating various thermodynamic properties of amino Sodium ascorbate synthesis solutions, i.e. excess Gibbs energy (gE) models used numerously to describe the solubility of amino acid solutions, and equations of state (EOS) mod
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Host cell invasion by tachyzoites relies on the secretion of
2020-05-15
Host cell invasion by tachyzoites relies on the secretion of numerous secretory proteins and plays a crucial role in maintaining infection [6]. ESA released by tachyzoites are highly immunogenic and induce either antibody-dependent or cell-mediated protective immunity [11], [44], [45]. To investigat
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With respect to the muscle compartment only low protein expr
2020-05-15
With respect to the muscle compartment, only low protein expression of ASB9 has been detected in healthy human skeletal muscle [as reported in the Human Protein Atlas (HPA)], whereas high levels of Asb5 protein expression are detected in mammalian skeletal muscle, which appears to be important in th
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Studies have focused on a hydrophobic cage at
2020-05-15
Studies have focused on a hydrophobic cage at the CULT domain, conserved from bacteria to mammals, as it binds to substrates and IMiDs (Chamberlain et al., 2014, Lupas et al., 2015). In addition, CRBN ligand-mediated protein degradation was highly conserved, which was confirmed in vertebrates by foc
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All components of the UPP were predicted
2020-05-15
All components of the UPP were predicted to be susceptible to oxidative stress due to the cysteine residues in their active sites [36]. Curcusone D inhibits DUBs but has no significant effect on the action of E1, E2s, E3s, or the proteasome, which indicates that the targets of the ROS induced by cu
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As CP is a crucial player in centriole
2020-05-15
As CP110 is a crucial player in centriole duplication, it is intriguing to ask whether centriole duplication would also be affected in the absence of the CP110-stabilizing effects of USP33. Li et al.[4] found that USP33 depletion did not inhibit normal centriole duplication through loss of centriole
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Currently approved anti obesity drugs for
2020-05-15
Currently approved anti-obesity drugs for long term use such as orlistat, lorcaserin and liraglutide are efficient in reduction of weight gain but are limited in usage due to their adverse effect profile and higher cost (Krentz et al., 2016; Mopuri and Islam, 2017). In Colchicine to this, plant der
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On the other hand the properties
2020-05-15
On the other hand, the properties of collagen materials could be efficiently improved by proper chemical modification. The crosslinking agents for collagen generally involve aldehydes (e.g., glutaraldehyde (GA), isocyanates (e.g., hexamethylene diisocyanate (HMDI), photoreactive agents, polyepoxy co
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The two SNPs rs rs
2020-05-15
The two SNPs rs4818-rs4680 presented above are part of the haploblock (rs6269, rs4633, rs4818, rs4680) presenting the 3 major haplotypes which influence the enzymatic activity of COMT. This activity is inversely related to the sensitivity of pain in a chronic pain syndrome; so the haplotype (GCGG) h
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Notably HSP expression is under control of the tetrameric fo
2020-05-15
Notably, HSP27 expression is under control of the tetrameric form of CK2 holoenzyme, as knockout or knockdown of the β regulatory subunit alone reproduces the same effects of targeting the α/α′ catalytic subunits. This observation discloses the possibility to use more specific drugs that affects onl
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Tiopronin Furthermore in silico physicochemical characters a
2020-05-15
Furthermore, in silico physicochemical characters and pharmacokinetic parameters for the synthesized compounds were predicted using dedicated computer software [34], [35], [36] to ensure successful in vivo therapeutic activity. Practical logP testing was performed and compared to the theoretical val
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In contrast irinotecan has shown much less myelosuppression
2020-05-15
In contrast, irinotecan has shown much less myelosuppression and may be more active in Ewing sarcoma both alone and in combination with temozolamide. One phase II study of 13 heavily pretreated Ewing sarcoma patients demonstrated a response rate of 38% including 2 complete responses (Bisogno et al.,
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In many studies spatial and
2020-05-14
In many studies, spatial and temporal expression and subcellular localizations of the DNMTs are examined in greater detail. These studies are evaluated and discussed in the remaining part of the article. DNMT1 protein expression was characterized in the genital ridge of the primitive mouse gonad at
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br Materials and Methods br Results
2020-05-14
Materials and Methods Results Discussion HSCs have been identified as major collagen-producing 1145 in the injured liver (1), and activation of HSCs has become the central link for liver fibrosis (2). The factors that regulate the biological behavior of HSCs include soluble regulatory fact
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br Diseases which have been treated with proteins
2020-05-14
Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty igf 1 inhibitor derivatives of human insulin bound to HSA have applications in the treatment of diabetes while pac
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