• In the early s in addition

  2024-06-19

  

  In the early 2000s, in addition to above-mentioned plant derived compounds, several peptide fragments from protein sources (e.g. gelatin, egg yolk, meat, fish, chicken, legumes) have been also confirmed as potential natural antioxidants and extensive studies about bioactive peptides have been conduc

• HMGN proteins are subject to extensive post translational

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  HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to p53 inhibitor and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in [175]). T

• The protein kinase CK mediated phosphorylation of HMGN was

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  The protein kinase CK2-mediated phosphorylation of HMGN1 was implicated to be involved in age-associated amnesia in rats [31]. It was shown that the decreased level of HMGN1 phosphorylation due to the down-regulation of CK2 activity could cause amnesia in aged rats, whereas the treatment with protei

• Previous research showed that combination of

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  Previous research showed that combination of chitosan and GSK-LSD1 hydrochloride nanocrystals (CNCs) can produce coating films with superior properties (Naseri, Mathew, Girandon, Fröhlich, & Oksman, 2015). CNCs are crystalline nanometer sized rod-like particles. It has been demonstrated that antimi

• Several studies have explored the

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  Several studies have explored the relationship between dental implants and MRONJ development. López-Cedrún JL et al. [13] reported that BRONJ developed after implant treatment in nine patients who were taking bisphosphonates orally. The mean interval between the initiation of treatment and the onset

• Recent retrospective cohort studies have supported these pre

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  Recent retrospective cohort studies have supported these preclinical findings in animals indicating the correlation of AR activation with the induction of atp citrate lyase carcinogenesis. First, men with prostate cancer who underwent androgen deprivation therapy were shown to have a significantly

• Dose Response Studies Against Puromycin Sensitive

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  Dose–Response Studies Against Puromycin–Sensitive Aminopeptidase (PSA). PSA is a ubiquitous metallopeptidase encoded by the NPEPPS gene with subcellular distribution in the cytosol and nucleus [49]. Comprising of a 919 amino β-Tocotrienol sequence, it has a broad substrate specificity, and is respo

• br Conclusion br Acknowledgement This

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  Conclusion Acknowledgement This study was supported by NIH/NINDSR01 NS036812-16. Introduction Lipoxygenases (LOXs) are a heterogeneous family of enzymes that catalyze the peroxidation of polyunsaturated fatty acids (PUFAs). By oxidizing free PUFAs, they were shown to contribute to the gene

• Lorlatinib is an orally active brain penetrant cyclic

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  Lorlatinib is an orally active brain penetrant cyclic 2-aminopyridine derivative that is a type I½ B ALK inhibitor (Fig. 5F) [61]. This medicinal is an effective antagonist against the more common L1196M and G1269A crizotinib-resistant mutations as well as the less common T1151Ins, L1152R, C1156Y, F

• br Conclusion br Introduction Lung cancer

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  Conclusion Introduction Lung cancer is the principal cause of death by cancer and the third most common cancer worldwide (Sorber et al., 2016). Lung cancer has two main types: small cell carcinomas (approximately 20%) and non-small cell lung cancers (NSCLC) (about 80%) (Fan et al., 2016). NSC

• Interestingly hypoxia and an enhanced Warburg effect ultimat

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  Interestingly, hypoxia and an enhanced Warburg effect ultimately lead to increased lactate production. The accumulation of lactate results in an acidic tumor microenvironment, which induces local inflammation. Lactate also promotes the polarization of macrophages that express immunosuppressive argin

• br Hypothesis The hypothesis is that AhR in

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  Hypothesis The hypothesis is that AhR in skin diseases could be an objective of study for future dermatological therapies. Both stimulation and inhibition of the receptor might have significant influences on neoplastic or inflammatory skin diseases. However, at present the functions of AhR are un

• Introduction Glaucoma consists of a group of eye diseases sh

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  Introduction Glaucoma consists of a group of eye diseases showing a broad spectrum of clinical presentation and unknown aetiologies, that lead to a permanent loss of visual function due to the death of retinal ganglion PHA-739358 and damage of the optical nerve. It is well accepted that a critical

• We found that several anticancer drugs inhibit HT receptor c

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  We found that several anticancer drugs inhibit 5-HT3 Epigenetics Compound Library australia current in vitro. Several studies have suggested that 5-HT3 receptor antagonists have anti-mitogenic and apoptotic effects on colorectal and breast cancer cell lines (Ataee et al., 2010, Hejazi et al., 2015)

• Introduction hydroxytryptamine HT is found throughout the bo

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  Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary LY2784544 (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The current classificat

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