• br Experimental br Acknowledgements This work was financiall

  2022-03-30

  

  Experimental Acknowledgements This work was financially supported by Ministry of Knowledge and Economy (10032113) and Ministry of Education, Science and Technology (20100000297). Introduction To ensure accurate chromosome segregation, cohesion between sister chromatids must be maintained u

• Our synthetic approach to GPR antagonists was designed

  2022-03-29

  

  Our synthetic approach to GPR55 antagonists was designed so that many different structures could be accessed to rapidly explore initial SAR, along with validating or modifying our current model (). The synthesis begins with the coupling of a carboxylic 5-Formyl-UTP to 4-piperidone by first forming

• Recent studies suggest that the biological importance of end

  2022-03-29

  

  Recent studies suggest that the biological importance of endogenous ghrelin becomes accentuated during exposure to more metabolically-constrained and stressful environments. Indeed, mice lacking either ghrelin or GHSR demonstrate impaired ability to adapt metabolically and/or behaviorally to caloric

• The potential therapeutic actions of GHSR in

  2022-03-29

  

  The potential therapeutic actions of GHSR in the central nervous system has been in the limelight lately. Peripheral administration of GHSR agonists have been shown to inhibit oxidative stress, apoptosis, proinflammatory cytokine production, microglia activation, mitochondrial dysfunction, and excit

• Experiments show that CSD propagation can be

  2022-03-29

  

  Experiments show that CSD propagation can be slowed or interrupted by pre-existing lesions or areas of high astrocytic density (Chen et al., 2006), and reduced expression of astrocytic gap junctions significantly increases the size of ischemic infarcts (Nakase et al., 2003). By decreasing the gap ju

• The role of GJs in liver fibrogenesis was

  2022-03-29

  

  The role of GJs in liver fibrogenesis was studied recently. Studies showed a significant decrease in liver fibrosis in Cx32 knockout mice compared to wild-type mice. Although the mechanism underlying this protective effect of Cx32 deletion is not clear, reduced oxidative stress was suggested as a po

• It has also been demonstrated that PS is ubiquitinated by

  2022-03-29

  

  It has also been demonstrated that PS1 is ubiquitinated by Caenorhabditis elegans SEL-10 [52], Fbw7 the mammalian homologue of SEL-10 [38], and more recently by tumour necrosis factor n-acetyl-l-cysteine associated factor 6 (TRAF6), which facilitates Lysine-63 (K63)-linked polyubiquitination of PS1

• br Materials and methods br Results Bgal from

  2022-03-29

  

  Materials and methods Results Bgal from Alteromonas sp. ML117 had an open reading frame of 3126 bp encoding 1042 amino ciprofloxacin residues with a predicted mass of 120 kDa and a theoretical pI (isoelectric point) of 5.44. The recombinant Bgal contained a His tag, as well as other additiona

• Similarly spectrophotometric titrations were carried out und

  2022-03-29

  

  Similarly, spectrophotometric titrations were carried out under conditions identical to those used for the fluorescence titrations. exhibited a predominant H-Lys(Ac)-OH.HCl band at around 493 nm. The titrations with all G-quadruplex DNAs resulted in a hypochromic effect along with a bathochromic

• G quadruplex structures can be resolved by

  2022-03-29

  

  G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer Wortmannin [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and discovered that

• Statins are recognized by their nephroprotective

  2022-03-29

  

  Statins are recognized by their nephroprotective effect (Chmielewski et al., 2002). The hepato- and nephroprotective effects of silymarin are also well studied (Alqasoumi, 2014, Mohamed et al., 2018). Several studies documented increasing Cy7 NHS ester of FXR by statins (Byun et al., 2014& (Lu et a

• So what makes a FFAR agonist different and interesting

  2022-03-29

  

  So what makes a FFAR1 agonist different and interesting? As shown in the , the cellular mechanism is different from those of present insulin-releasing pharmacotherapies—namely the secretion initiators (sulphonylureas and meglitinides) and the incretin-based secretion potentiators (glucagon-like pept

• Although angiogenesis is crucial for cerebral ischemic rehab

  2022-03-28

  

  Although angiogenesis is crucial for cerebral ischemic rehabilitation, the mechanism underlying NGF promotion of angiogenesis is not clear. Previous studies showed that angiogenesis can be promoted by FAK, in a breast cancer model [19]. Recent studies showed that FAK phosphorylation participated in

• br Place in Therapy In

  2022-03-28

  

  Place in Therapy In the case of minor bleeding, the anticoagulant effects of all FXa inhibitors except betrixaban, which has a longer half-life, will diminish within 24-48 hours of discontinuation of the drug provided the patient has normal renal function. In these cases stopping the FXa inhibito

• One PKC target that controls cortical actin structure

  2022-03-28

  

  One PKC target that controls cortical 6-Chloromelatonin structure is a well-known actin crosslinking protein, myristoylated alanine-rich C-kinase substrate (MARCKS). MARCKS cross-links actin and binds PIP2 and this binding activity is regulated by PKC phosphorylation [82]. Activation of PKC releases

14770 records 407/985 page Previous Next First page 上5页 406407408409410 下5页 Last page