• In Arabidopsis GCN containing protein complexes are found

  2021-11-20

  

  In Arabidopsis, GCN5-containing protein complexes are found to be involved in cell differentiation, leaf and floral organogenesis [[8], [9], [10]]. AtHAC1 has involvement with root elongation, flowering, fertility and de novo shoot regeneration [11,12]. AtHAM1 and AtHAM2 control flowering time by ep

• There are also data showing potential beneficial effects

  2021-11-20

  

  There are also data showing potential beneficial effects of SGLT2i on non-alcoholic fatty liver disease (NAFLD) [[14], [15], [16], [17]], a hepatic manifestation of the metabolic syndrome that has been linked to type 2 diabetes mellitus (T2DM) development and increased cardiovascular (CV) as well as

• The identity of the K transport pathway activated by NEM

  2021-11-19

  

  The identity of the K+ transport pathway activated by NEM remains unclear. The pathway does not require the presence of Gardos channel KCNN4 or K–Cl cotransporters KCC3 and KCC1, but like these pathways is sensitive to the presence of hemoglobin S or other sickling hemoglobins. Although partially se

• The schematic diagram of the antagonistic interactions of

  2021-11-19

  

  The schematic diagram of the antagonistic interactions of Zn2+ and neurosteroids (NSs) at GABA-A receptors is summarized in Fig. 7. Neurosteroids exhibit powerful seizure protective effects against experimental seizures probably through the potentiation of synaptic and extrasynaptic GABA-A receptor-

• br Results br Discussion Glucose homeostasis is regulated

  2021-11-19

  

  Results Discussion Glucose homeostasis is regulated by a complex and intricate signaling network involving multiple organs. The BA nuclear receptor FXR is integrated into this regulatory network and participates in glucose handling and metabolism. Intestinal FXR favors glucose Phenytoin sodium

• br Results and discussion Computer modelling

  2021-11-19

  

  Results and discussion Computer modelling studies suggested that the endocyclic oxygens in furocoumarin derivatives, such as Alisol A 3a (Fig. 1), could also coordinate metal ions in the HIV-1 IN enzyme active site and inhibit the integration of viral DNA. The coumarin moiety is found in various

• Evidence indicates that astrocytes play a role in the modula

  2021-11-19

  

  Evidence indicates that astrocytes play a role in the modulation of NMDAR activity in the CA1 (Henneberger et al., 2010; Papouin et al., 2017a, Papouin et al., 2017b; Robin et al., 2018). Therefore, we sought to examine whether astrocytes are involved in the H1 receptor antagonist/inverse agonist-in

• Diabetes and atherosclerosis are paralleled by impaired woun

  2021-11-19

  

  Diabetes and atherosclerosis are paralleled by impaired wound healing and endothelial angiogenesis in the periphery, which cause severe complications and mainly occur as a result of the elevated circulating levels of glucose and free fatty acids. Yuan et al. recently showed that palmitic Thienoguano

• br Acknowledgements br Introduction Pregnancy brings forth s

  2021-11-19

  

  Acknowledgements Introduction Pregnancy brings forth significant metabolic reprogramming that induces a number of metabolic changes to ensure that the nutrient requirements of the mother and fetus are met [[1], [2], [3]]. These adaptations change radically over the period of pregnancy dependin

• br Introduction Soluble guanylyl cyclase GC maintains vascul

  2021-11-19

  

  Introduction Soluble guanylyl cyclase (GC-1) maintains vascular function through the NO/GC-1/cGMP pathway [1,2] by catalyzing the conversion of GTP into cGMP (Fig. 1). The GC-1 heme prosthetic group binds NO with picomolar affinity, resulting in a 100- to 200-fold increase in catalytic activity.

• br STAR Methods br Acknowledgments Anthony Koleske

  2021-11-19

  

  STAR★Methods Acknowledgments Anthony Koleske is thanked for helpful discussions and for providing p190RhoGAP-A cDNA. Anatoly Kiyatkin and Mark Lemmon are thanked for use of the BioTek Synergy 2 plate reader for the MANT assays. Leena Kuruvilla is thanked for assistance with the thermal shift a

• br Material and methods br Results Consistent

  2021-11-19

  

  Material and methods Results Consistent with our previous study, SR-SIM and confocal microscopy showed a large number of IBA1-expressing Triciribine synthesis in all parts of the human cochleae (Fig. 1). IBA1, the microglial and macrophage-specific calcium-binding protein, is involved in the

• Histamine functions as a key neurotransmitter in multiple ci

  2021-11-18

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, Efaproxiral Sodium is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recyclin

• Through the analysis of various

  2021-11-18

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic Triamcinolone motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of discovering

• br Conclusions Temporally controlled disruption

  2021-11-18

  

  Conclusions Temporally-controlled disruption of Gcgr reveals a lack meaningful contribution to the improvement of glycemic control in insulinopenic conditions attributable to the intrinsic loss of GCGR signaling. On the other hand, these data highlight the importance of compensatory systems, incl

15399 records 525/1027 page Previous Next First page 上5页 521522523524525 下5页 Last page