• Herbal products may alter the metabolism of certain drugs an

  2021-01-15

  

  Herbal products may alter the metabolism of certain drugs and, likewise, the metabolism of components of herbal products may be altered by some drugs, specifically those that affect cytochrome P450 new relationships (CYP). These can bring about an alteration of the pharmacokinetics and pharmacologi

• To elucidate whether the impact of hypoxia

  2021-01-15

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer BI-847325 driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and poorly diff

• br Ubiquitin Capture by the

  2021-01-15

  

  Ubiquitin Capture by the Mobile APC11 RING Domain Contributes to Processive Substrate Ubiquitylation Although the rules of Ub-mediated proteolysis are only beginning to emerge, the rate and order in which different APC/C substrates are degraded during the epirubicin correlates with processivity o

• GS-9973 We hypothesized that the atopic

  2021-01-15

  

  We hypothesized that the atopic phenotype may be partially influenced by an altered binding and/or signalling due to the amino-acid substitution in the receptor protein. The principal aim of this study was to investigate the signalling mechanisms of the variants CysLT1-G300S and CysLT1-I206S induced

• In recent years the use of

  2021-01-15

  

  In recent years, the use of liquid chromatography/tandem mass spectrometry (LC–MS/MS) has become a preferred approach to measure drugs and metabolites in biological fluids due to its very high selectivity and sensitivity [17], [18], [19], [20], [21], [22], [23], [25], [30]. The great sensitivity of

• br Introduction Alzheimer s disease AD

  2021-01-15

  

  Introduction Alzheimer’s disease (AD) is the progressive version of mild cognitive impairment and usually met by the elderly population. It falls into the class of neurodegenerative disorders that attacks the RGDfK nerves cells, or neurons, resulting in loss of memory, impairment of thinking and

• Fosmidomycin sodium salt br The LSCP model and

  2021-01-15

  

  The LSCP model and its properties In this section, we first introduce the LSCP model in Section 2.1. Some examples of the model are presented in Section 2.2 and basic properties of the model are presented in Section 2.3. Finally, Section 2.4 introduces finite dimensional approximations necessary

• Materials and Methods br Results br Discussion For several

  2021-01-14

  

  Materials and Methods Results Discussion For several decades, the diagnosis of translocation-associated childhood sarcomas with overlapping morphological characteristics has been facilitated by pathognomonic gene fusion detection through RT-PCR or FISH. However, these assays have several shor

• br Conflicts of interest br Acknowledgements This work was s

  2021-01-14

  

  Conflicts of interest Acknowledgements This work was supported, in part or in whole, by the grants from the National Natural Science Foundation of China (11802056, 11772088), the China Postdoctoral Science Foundation (2018M640904), and the Fundamental Research Funds for the Central Universitie

• Furan analogs and N methylpyrrole analogs had completely

  2021-01-14

  

  Furan analogs and N-methylpyrrole analogs had completely different SARs. For example, replacement of the furan-2-sulfonyl moiety of 6 with the furan-3-sulfonyl moiety resulted in 8 with a decreased EP1 Hydrocortisone affinity and an increased antagonist activity, while the corresponding chemical mod

• Moreover considering that several polyphenols and flavonoids

  2021-01-14

  

  Moreover, considering that NMS-873 receptor several polyphenols and flavonoids (i.e. chalcones, flavanones, resveratrol derivatives, ellagic acid) are reported to inhibit tyrosinase and elastase (Pillaiyar et al., 2017; Xing et al., 2016; Wittenauer et al., 2015), the relations between enzyme inhibi

• It is interesting to note that our

  2021-01-14

  

  It is interesting to note that galactoside our results show a very similar behavior in binding of DDR2 ECD to immobilized a-telo (bovine-dermal) versus telo- (rat-tail) collagen I as a function of its oligomeric state. Thus, the telopeptide region of tropocollagen exerts little influence on DDR2-col

• In general cellular senescence is considered a programmed re

  2021-01-14

  

  In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200

• Aprepitant br Materials and methods br

  2021-01-14

  

  Materials and methods Results Discussion Regardless of obvious beneficial effects of GC on acceleration of foetal lung and cardiomyocytes maturation (Kamath-Rayne et al., 2012; Rog-Zielinska et al., 2015), the current study revealed that GC exposure during late pregnancy induces IR and alte

• br Experimental methods br Results and discussion br Conclus

  2021-01-14

  

  Experimental methods Results and discussion Conclusion Rational design of highly selective fluorescent probes to detect G-quadruplexes is of profound importance for basic research. On this basis, we designed and synthesized a series of N-alkylated styrylquinolinium dyes Ls-1, Ls-2 and Ls-3.

15399 records 700/1027 page Previous Next First page 上5页 696697698699700 下5页 Last page