• Nimodipine is an L type calcium

  2020-05-16

  

  Nimodipine is an L-type calcium channel antagonist that reduces excessive calcium influx during pathological conditions, contributing to its neuroprotective properties (Zornow and Prough, 1996; Kobayashi and Mori, 1998). Autophagy can be induced by increased [Ca2+] (Rami et al., 2008). Nimodipine si

• MMP-2/MMP-9 Inhibitor I synthesis In conclusion we have foun

  2020-05-16

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response MMP-2/MMP-9 Inhibitor I synthesis at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to

• br Conclusions In conclusion we identified

  2020-05-16

  

  Conclusions In conclusion, we identified and overexpressed DGAT2 in fast growing, oleaginous N. oceanica for the first time. The engineered N. oceanica overexpressing DGAT2 resulted in enhanced neutral lipid accumulation and altered fatty wst-1 assay composition. Altogether, our findings demonst

• br Materials and methods br Results br Discussion The

  2020-05-16

  

  Materials and methods Results Discussion The first DGAT1 gene was described in the mouse in 1998 [28], and a few years later DGAT2 was identified from the oleaginous fungus Mortierella ramanniana[29]. Although both of them are known as the primary enzymes for de novo TAG biosynthesis, they

• One possible explanation for differences in the

  2020-05-16

  

  One possible explanation for differences in the binding ability of monomeric versus dimeric forms of DDR2 ECD to collagen could be that the monomeric form only binds to the primary GVMGFO site, whereas dimeric (and oligomeric) DDR2 ECD binds to additional sites on the collagen triple-helical molecul

• During recent years two primary types of

  2020-05-15

  

  During recent years, two primary types of models have been applied for calculating various thermodynamic properties of amino Sodium ascorbate synthesis solutions, i.e. excess Gibbs energy (gE) models used numerously to describe the solubility of amino acid solutions, and equations of state (EOS) mod

• Host cell invasion by tachyzoites relies on the secretion of

  2020-05-15

  

  Host cell invasion by tachyzoites relies on the secretion of numerous secretory proteins and plays a crucial role in maintaining infection [6]. ESA released by tachyzoites are highly immunogenic and induce either antibody-dependent or cell-mediated protective immunity [11], [44], [45]. To investigat

• With respect to the muscle compartment only low protein expr

  2020-05-15

  

  With respect to the muscle compartment, only low protein expression of ASB9 has been detected in healthy human skeletal muscle [as reported in the Human Protein Atlas (HPA)], whereas high levels of Asb5 protein expression are detected in mammalian skeletal muscle, which appears to be important in th

• Studies have focused on a hydrophobic cage at

  2020-05-15

  

  Studies have focused on a hydrophobic cage at the CULT domain, conserved from bacteria to mammals, as it binds to substrates and IMiDs (Chamberlain et al., 2014, Lupas et al., 2015). In addition, CRBN ligand-mediated protein degradation was highly conserved, which was confirmed in vertebrates by foc

• All components of the UPP were predicted

  2020-05-15

  

  All components of the UPP were predicted to be susceptible to oxidative stress due to the cysteine residues in their active sites [36]. Curcusone D inhibits DUBs but has no significant effect on the action of E1, E2s, E3s, or the proteasome, which indicates that the targets of the ROS induced by cu

• As CP is a crucial player in centriole

  2020-05-15

  

  As CP110 is a crucial player in centriole duplication, it is intriguing to ask whether centriole duplication would also be affected in the absence of the CP110-stabilizing effects of USP33. Li et al.[4] found that USP33 depletion did not inhibit normal centriole duplication through loss of centriole

• Currently approved anti obesity drugs for

  2020-05-15

  

  Currently approved anti-obesity drugs for long term use such as orlistat, lorcaserin and liraglutide are efficient in reduction of weight gain but are limited in usage due to their adverse effect profile and higher cost (Krentz et al., 2016; Mopuri and Islam, 2017). In Colchicine to this, plant der

• On the other hand the properties

  2020-05-15

  

  On the other hand, the properties of collagen materials could be efficiently improved by proper chemical modification. The crosslinking agents for collagen generally involve aldehydes (e.g., glutaraldehyde (GA), isocyanates (e.g., hexamethylene diisocyanate (HMDI), photoreactive agents, polyepoxy co

• The two SNPs rs rs

  2020-05-15

  

  The two SNPs rs4818-rs4680 presented above are part of the haploblock (rs6269, rs4633, rs4818, rs4680) presenting the 3 major haplotypes which influence the enzymatic activity of COMT. This activity is inversely related to the sensitivity of pain in a chronic pain syndrome; so the haplotype (GCGG) h

• Notably HSP expression is under control of the tetrameric fo

  2020-05-15

  

  Notably, HSP27 expression is under control of the tetrameric form of CK2 holoenzyme, as knockout or knockdown of the β regulatory subunit alone reproduces the same effects of targeting the α/α′ catalytic subunits. This observation discloses the possibility to use more specific drugs that affects onl

14740 records 773/983 page Previous Next First page 上5页 771772773774775 下5页 Last page