• We found that the postnatal absence of norepinephrine yields

  2020-03-30

  

  We found that the postnatal absence of norepinephrine yields differing effects depending on noradrenergic receptor type and synthase region. The density of α1-AR, indicated by [3H]prazosin binding was similar between Dbh+/− and Dbh−/− mice except for a significant increase in hippocampus in Dbh−/−

• In the present study the

  2020-03-30

  

  In the present study, the mineralocorticoid receptor of the CYP2C11 gene and the levels of its protein and activity were decreased in rats with liver insufficiency and in rats after induced dysfunction of the serotonergic system during normal liver function. Moreover, serotonergic system dysfunctio

• br Pre clinical combination studies using

  2020-03-30

  

  Pre-clinical combination studies using CSF-1/CSF-1R inhibitors In preclinical models, the CSF-1R pathway can be blocked by using either small molecule kinase inhibitors (GW2580 [30], PLX3397 [31], Ki20227 [32], BLZ945 [33] and CYC11645 [34]), antibody-mediated inhibition of CSF-1 using 5A1 [35] o

• br Results br Discussion Drug resistance

  2020-03-30

  

  Results Discussion Drug resistance poses the greatest hurdle of achieving high efficacy with AADs in cancer patients. AAD-treated cancer patients often encounter intrinsic and evasive drug resistance that diminishes the therapeutic efficacy to only minor survival benefits in most cancer types.

• Various domains of the HSA molecule

  2020-03-30

  

  Various domains of the HSA molecule have also been used to make bioconjugates with increased stability, better targeting properties, and/or extended half-lives in blood. For example, domain I of HSA has been used in the preparation of antibody conjugates. This was achieved through the use of a cyclo

• Introduction Determining how genes function

  2020-03-30

  

  Introduction Determining how genes function together as biological systems is a defining challenge of the genomic era. While genome sequences reveal the DNA blueprint of organisms, deciphering how this blueprint leads to biological function is challenging due in large part to the complexity of prot

• The acetylcholinesterasic activity of exposed animals after

  2020-03-30

  

  The acetylcholinesterasic activity of exposed animals, after treatment with diverse concentrations of uranium and following distinct recovery periods, remained unaltered for all species. This finding suggests that uranium, in spite of being a water-soluble metal, does not exert any effect on the sel

• In the horse oviduct the EP receptor was most

  2020-03-27

  

  In the horse oviduct, the EP2 receptor was most strongly expressed in epithelial kainate receptor particularly in nonciliated (secretory) epithelial cells as evidenced by IHC. Furthermore, relative amount of EP2 mRNA was greater in the ampulla than in the isthmus, although this likely reflects diff

• br Transparency document br Acknowledgements We thank

  2020-03-27

  

  Transparency document Acknowledgements We thank Prof. Barbara Brodsky for valuable comments and discussion. We thank the support of the Tufts start-up fund and the Knez Family Faculty Investment Fund for Y.-S. L, and the Tufts Summer Scholar program for E.C. Introduction Discoidin domain r

• It is particularly notable that

  2020-03-27

  

  It is particularly notable that CYP2D6 appears to be the most stable of the major CYP450 pitavastatin in its expression over time in vitro and appears to be least affected by culture conditions and sample to sample variability (i.e., CYP2D6 expression is remarkably consistent over time and between i

• The lack of robust immunocompetent animal models permissive

  2020-03-27

  

  The lack of robust immunocompetent animal models permissive for HCV makes it hard to assess if the quantity and quality of vaccine-induced immunity is sufficient to confer protection. Thus, it is difficult to predict to what extent antibody responses induced by current vaccination approaches, includ

• One of the most frequent gene alterations in MM

  2020-03-27

  

  One of the most frequent gene alterations in MM is methylation of the p15 and p16 genes in the 5′ upstream region. P15 and p16 proteins are Pemetrexed regulators involved in the inhibition of transition from G1 to S phase. Frequencies of p15 or p16 gene methylation up to 32% and 53%, respectively,

• br Conclusion Blueberry is becoming a worldwide crop

  2020-03-27

  

  Conclusion Blueberry is becoming a worldwide crop with the fastest rising consumer demand trends for its health benefits. However, the berry size is one of the key parameters for determining fruit quality and consumers’ preferences (Milic et al., 2018). Understanding the physiological and molecu

• br CXCR CXCR is a homeostatic chemokine

  2020-03-27

  

  CXCR5 CXCR5 is a homeostatic chemokine receptor for lymphocytes and plays a critical role in the development of lymphoid organs as well as regulating the interaction between antigen presenting cells and lymphocytes (Cannons et al., 2012). It is one of the major chemokine receptors dictating norma

• To the best of our knowledge this

  2020-03-27

  

  To the best of our knowledge, this study was the first to demonstrate in vitro and in vivo that the lipolytic effect of kinsenoside results from coordination between PKA and AMPK pathways. We validated the lipolytic effect of kinsenoside in vivo and the effect of PKA activation on the modulating AMP

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