• TraM is one of two

  2019-12-19

  

  TraM is one of two transfer proteins from pIP501 T4SS that have structural similarity to the A. tumefaciens VirB8 protein (Fercher et al., 2016, Goessweiner-Mohr et al., 2013), a central member of the inner membrane complex (Bailey et al., 2006, Guglielmini et al., 2014, Trokter et al., 2014). VirB8

• In order to further understand the biological significance o

  2019-12-19

  

  In order to further understand the biological significance of cell-collagen X interactions, we have examined the possibilities of involvement of other collagen receptors in cell binding to collagen X. The present study demonstrates that collagen X is a ligand for DDR2. DDR2 has been observed to bind

• Multi subunit RING type E ligases are

  2019-12-19

  

  Multi-subunit RING-type E3 ligases are exemplified by the CULLIN-RING-ligase (CRL) and the anaphase-promoting complex/cyclosome (APC/C) [19]. CRLs constitute the biggest family of other multi-component E3 ligases. These consist of a cullin scaffold protein (CULLIN 1, 2, 3, 4A, 4B, 5, 7), a substrate

• Initially studies of GPCRs predominantly assessed

  2019-12-18

  

  Initially, studies of GPCRs predominantly assessed the signalling pathways downstream of receptors on the cell surface. There is now an understanding that GPCRs can localize to and signal from various intracellular compartments, such as the nucleus (reviewed in [40]). These intracellular pools of re

• Importantly our in vivo data fit to the in vitro

  2019-12-18

  

  Importantly, our in vivo data fit to the in vitro data, further confirming the synergistic effect of XJD and gefitinib on the inhibition of lung cancer and the regulation of SP1, HOTAIR, and EP4 Ferulenol levels. The doses of XJD used were based on our previous in vivo study (Zhao et al., 2016). We

• br Transparency document br Acknowledgements

  2019-12-18

  

  Transparency document Acknowledgements We thank Prof. Barbara Brodsky for valuable comments and discussion. We thank the support of the Tufts start-up fund and the Knez Family Faculty Investment Fund for Y.-S. L, and the Tufts Summer Scholar program for E.C. Introduction Discoidin domain r

• Why are Tfh cell dynamics so

  2019-12-18

  

  Why are Tfh cell dynamics so fundamentally different in naive and immune animals? Initially, GC see more must pass stringent affinity and specificity checkpoints to ensure only high-affinity non-self-reactive cells are selected. Therefore, restricting primary Tfh cells with the greatest helper capac

• Programmed cellular death or apoptosis is a process genetica

  2019-12-18

  

  Programmed cellular death or apoptosis is a process genetically controlled that plays an important role in cellular homeostasis, being an important defense mechanism to remove cells that have been infected, damaged or mutated (Smith and Smith, 2012, Wlodkowic et al., 2011). Nevertheless, apoptosis s

• CM AVM and VOGM are thought to be two

  2019-12-18

  

  CM-AVM and VOGM are thought to be two distinct disorders, with CM-AVM characterized by atypical CMs, with or without AVM in variable body parts, while VOGM is a type of cerebral AVM [16]. The fact that VOGM is infrequently reported as the AVM in CM-AVM patients, and CMs are quite often identified in

• Several studies on the collagen receptor

  2019-12-18

  

  Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR Kif15-IN-2 on collagens are distinct from integrin binding sites; therefore, the same collagen protein can bind to DDR and i

• In conclusion our findings demonstrated that

  2019-12-18

  

  In conclusion, our findings demonstrated that S1PC augments HMOX1 expression in a NO-dependent manner, and its effects are associated with the enhancement of BACH1 degradation. In addition, S1PC and NO potentially degrade BACH1 based on the observation that nuclear degradation of BACH1 differs from

• The development of novel approaches to study

  2019-12-18

  

  The development of novel approaches to study GPCR-mediated transactivation in live Sulfo-NHS-Biotin is important, and this study describes a unique BRET-based quantification of Grb2 recruitment to the EGFR as a direct readout of GPCR-mediated transactivation. We have previously used the recruitment

• As an endogenous negative modulator CRBN inhibits AMPK s

  2019-12-18

  

  As an endogenous negative modulator, CRBN inhibits AMPK’s activation (phosphorylation of Thr172) by directly binding to the α-subunit of AMPK, disrupting γ-subunit recruitment to the AMPK complex (Lee et al., 2011, Lee et al., 2013). In our study, we did not focus on AMPK activation, since only a si

• HOIP s ability to build linear Ub chains arises

  2019-12-18

  

  HOIP\'s ability to build linear Ub chains arises from a unique domain that follows directly after the RING2 domain, the linear ubiquitin chain-determining domain (LDD) (Fig. 1). Structures have revealed that the LDD is structurally integrated into RING2, creating a single RING2–LDD unit (Fig. 2D) [4

• br Materials and methods br

  2019-12-18

  

  Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important Verteporfin of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the phosphorylation sys

14723 records 845/982 page Previous Next First page 上5页 841842843844845 下5页 Last page