• The other interesting observation made during this

  2019-10-15

  

  The other interesting observation made during this study relates to the differences between the discrete IR-induced γH2AX foci and the robust H2AX phosphorylation observed during apoptotic DNA fragmentation. The pattern of H2AX phosphorylation observed during DNA fragmentation possibly reflects the

• During these processes meiotic recombination plays a critica

  2019-10-15

  

  During these processes, meiotic recombination plays a critical role by physically associating homologs and ensures accurate chromosome segregation. In addition, meiotic recombination redistributes genetic material between homologs, resulting in haplotype diversity among progeny, impacting ecological

• In the belief that DNA

  2019-10-15

  

  In the belief that DNA-based nanosensors and DNA microarrays should be easier to operate, faster, more accurate and more economically viable than PCR-based techniques, an electrochemical DNA biosensor was designed for detection of G. boninense[9], [10]. This was developed based on a gold electrode m

• br Introduction The stroma associated with breast cancer met

  2019-10-15

  

  Introduction The stroma associated with breast cancer metastasis consists of extracellular matrix (ECM) proteins, including fibrillar collagens, and a cellular component comprised of mesenchymal stem/multipotent stromal GSK-3 Inhibitor IX (MSCs), vessels, and cells of the immune system (Pein and

• desogestrel Air trapping at the small airways is related

  2019-10-15

  

  Air-trapping at the small airways is related to severe desogestrel (Bjermer, 2014), and acute exacerbation (Mahut et al., 2010). Although asthma patients are generally treated with inhaled corticosteroid (ICS) or with ICS and long-acting β2 agonist (LABA), the efficacy of such treatment depends on

• Since its inception ADEPT approach has been widely reported

  2019-10-15

  

  Since its inception, ADEPT approach has been widely reported by many groups using a variety of enzymes and prodrugs (see reviews) [12], [14]. Both mammalian and non-mammalian enzymes have been utilised. Of the mammalian variety, human β-glucuronidase in combination with many prodrugs [17], [18] and

• rotenone and Coumarins also known as benzopyran ones are a

  2019-10-15

  

  Coumarins also known as benzopyran-2-ones are a family of nature-occurring lactones first isolated from Tonka beans in 1820. They are an important class of oxygen containing heterocycles widely found in nature, so much so that they have been routinely employed as herbal remedies since early days. Ov

• Maprotiline HCl and In the present study we examined

  2019-10-15

  

  In the present study we examined whether the gene for estrogen receptor alpha, Esr1, plays a role in the expression of maternal memory in female rats. The approach utilized a newly developed rat Esr1 knockout (KO) rat model (Rumi et al., 2014) to evaluate whether deletion of the Esr1 Maprotiline HCl

• In order to evaluate the in vivo

  2019-10-15

  

  In order to evaluate the in vivo pharmacology associated with EP receptor antagonism, we wished to discover antagonists presenting a higher degree of selectivity over the other prostanoid receptors. We also wanted to increase the brain–blood ratio since it is probable that centrally mediated EP agon

• br Discussion The present results demonstrate

  2019-10-14

  

  Discussion The present results demonstrate that high dose estrogen–progestogen OC treatment produced impaired glucose tolerance and glucose tolerance was preserved during low dose estrogen–progestogen, high or low dose progestogen-only OC use. The study also shows that impaired glucose tolerance

• EphB promotes tumor growth by stimulating angiogenesis throu

  2019-10-14

  

  EphB4 promotes tumor growth by stimulating angiogenesis through EphrinB2 [18]. However, the distinct and specifically involvement of EGTA and veins in the tumor angiogenesis of all tumor grades is unclear. Our results indicate that the relation between EphrinB2 and EphB4 stained blood vessels was al

• The prospects of the use of this novel

  2019-10-14

  

  The prospects of the use of this novel approach for the selective local thermo-activation of enzymes include biomedical and biotechnological applications. As NPs could be engineered to gain access to Quinidine through the endosomal compartment [47] or through non-endocytotic pathways [48], [49], [5

• 3466 Our present data show that neuroleptics can

  2019-10-14

  

  Our present data show that neuroleptics can affect CYP3A via a direct interaction with the enzyme and a significant indirect mechanism (enzyme regulation) produced in vivo. The obtained results revealed interactions of the neuroleptics (added in vitro to control liver microsomes, Model I) with rat C

• The BDNF Val Met polymorphism is

  2019-10-14

  

  The BDNF Val66Met polymorphism is also associated with decreased dendritic arborization and impaired long-term potentiation [25]. This is particularly important for the hippocampus, and healthy individuals with a BDNF Val66Met allele have decreased hippocampal volumes [30]. Hippocampal atrophy is co

• br Materials and methods br Results and

  2019-10-14

  

  Materials and methods Results and discussion Conclusions Given that the activity of anti-plant virus compounds is related to host tobacco, virus, and compounds, we determined the effect of anti-CMV compound NNM on defense enzyme activity and chlorophyll index in tobacco, and we used RIB as

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