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Introduction The carnitine choline acyltransferase family is
2019-08-23
Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) HG-10-102-01 and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this family consists of s
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Damage of PE HD due to both mechanisms
2019-08-23
Damage of PE-HD due to both mechanisms is usually considered to emerge from a local stress concentration in the material, leading to the initiation of a crack, which subsequently propagates further through the material, and finally leads to macroscopic failure. In this process, crack growth occurs o
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To develop novel EPAC inhibitors Zhou and co
2019-08-23
To develop novel EPAC inhibitors, Zhou and co-workers optimized the HTS hit as the chemical lead. After modifications of the substituents on the phenyl ring or C6-position of compound , compound () was identified to be the more potent compound in this series with an IC value of 4.0µM (EPAC2). Dock
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Keeping the cofactor content oligomeric
2019-08-22
Keeping the cofactor content, oligomeric state, subcellular localization, and membrane association in view, DHODH has been broadly divided into two classes, class 1 and class 2 [26], [27]. In many species it is present to either cytoplasm (Class 1) or to the inner mitochondrial membrane (or plasma m
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br Steroid biosynthesis br Steroid hormone metabolism in bre
2019-08-22
Steroid biosynthesis Steroid hormone metabolism in breast cancer Conclusion Steroid hormones elicit their biological actions primarily by binding to steroid receptors such as the ER, AR, PR and GR. Although classical breast cancer diagnostic panels assess the expression of the ER and PR, as
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First of all it should be emphasized that
2019-08-22
First of all, it should be emphasized that, although cPLA2α manifests a marked selectivity for phospholipids that contain AA at the sn-2 position, this does not mean in any way that, in cells, the enzyme cannot hydrolyze other fatty acyl residues to a significant extent even if this occurs at a lowe
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Sequence alignment of cfALDH with the human ALDH indicates
2019-08-22
Sequence alignment of cfALDH with the human ALDH1 indicates that the cyanobacterial protein contains the same GQCC motif as the human ALDH1 and ALDH2 proteins [24] (Fig. 1d, highlighted in red, and Supplementary Fig. 2). This motif is present in ALDH1/2 orthologues and these residues reside at the b
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br Discussion Immune response to CMV is a series
2019-08-21
Discussion Immune response to CMV is a series cell-mediated immune response initiated by innate innate NK cells, followed by adaptive CD8+ and CD4+ T cells and humoral immunity by B cell [3]. Prior to transplant, measurement of humoral immune responses (CMV serology) of donor and recipient is com
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The anticholinesterase activities of all subfractions derive
2019-08-21
The anticholinesterase activities of all subfractions derived from EtOAc extract were detected and summarized in . Fraction 5 and its resulting subfractions (5B, 5C, 5D, 5C3, 5C4, 5D3, and 5D4) were found to show attractive activities. Subsequently, ten compounds (–) were obtained from these active
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It is common for plants
2019-08-21
It is common for plants that are deficient in P to invest in their roots in order to maximise P uptake from the soil. Here, plants grown in soil amended with OA had a higher root biomass:shoot apomorphine ratio compared with plants in the INORG-P treatment. Additionally, greater allocation of C to
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br Conclusions br Acknowledgements br
2019-08-21
Conclusions Acknowledgements Protein tyrosine kinases (PTKs) of Src family are important components in cellular signal transduction pathways that couple diverse extracellular signals to appropriate cellular responses . Their activities are tightly regulated in the cells and aberrant activati
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The need for dedicated DAPT updates is well
2019-08-21
The need for dedicated DAPT updates is well justified by the large amount of data and new information generated in the field over the past few years. As expected, the ACC/AHA and ESC updates contain large areas of overlap as well as some differences. Differences were largely explained by the differe
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Importantly our in vivo data fit to the in vitro
2019-08-21
Importantly, our in vivo data fit to the in vitro data, further confirming the synergistic effect of XJD and gefitinib on the inhibition of lung cancer and the regulation of SP1, HOTAIR, and EP4 fibronectin definition levels. The doses of XJD used were based on our previous in vivo study (Zhao et a
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At the therapeutic level the logical approach to address the
2019-08-21
At the therapeutic level, the logical approach to address the cooperation between FGFR4 and EGFR was the combined inhibition of both receptors. To explore the potential efficacy and specificity of this approach, we tested the effect of FGFR and EGFR inhibitors in monotherapy or in combination in syn
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Nitric oxide NO is synthesized by conversion
2019-08-21
Nitric oxide (NO) is synthesized by conversion of the l-arginine to NO and l-citrulline through reaction which is catalyzed by nitric oxide synthetase (NOS) (Knowles and Moncada, 1994). NO as an important molecule not only play a role as second messenger but also binds to cytochrome c oxidase and de
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