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Recent progress has been made in translating
2024-07-26
Recent progress has been made in translating animal findings on memory performance and amnestic effects – that are largely determined by tonically active receptors in which α5 contributes to the benzodiazepine binding site. Based on the observation that deletion of this subunit led to improved spati
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It is well known that neurosteroids such as
2024-07-26
It is well-known that neurosteroids such as testosterone and their metabolites endogenously modulate neural excitability in animals and humans. Testosterone has protective effects against seizures induced by KA and PTZ (Frye et al., 2001b; Reddy, 2004b). Estrogens, on the other hand, have proconvuls
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There is little question that as we become more
2024-07-26
There is little question that as we become more proficient in the diagnosis of arginase 1 deficiency individuals with intermediary elevations in arginine on newborn screening and partial defects in enzymatic activity will be found. There are no reliable data to determine a safe level of arginine and
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br Conclusions br Acknowledgements We would like
2024-07-26
Conclusions Acknowledgements We would like to thank the members of the Bergmann lab for fruitful discussions in the course of this work. This work was supported by the National Institute of General Medical Sciences (NIGMS) under award number R35 GM118330. The content is solely the responsibili
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Gene regulation of MMPs is influenced
2024-07-26
Gene regulation of MMPs is influenced by the transcription factor activating factor-1 (AP-1). AP-1 complexes are heterodimers of proteins of the two proto-oncogene families (jun and fos) and have Ivabradine HCl receptor in the promoter region of MMPs, as well as in genes mediating inflammatory resp
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Introduction Antimicrobial resistance is a growing health th
2024-07-26
Introduction Antimicrobial resistance is a growing health threat worldwide that has been associated with incorrect prescription and overuse of reverse transcriptase [1]. Considering that physicians play a central role in antibiotic usage, a better understanding of their prescribing behaviours and
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Numerous epidemiological studies document fewer
2024-07-26
Numerous epidemiological studies document fewer cardiovascular events and increased survival of non-CKD individuals treated with angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARBs) [8], [9]. By contrast, there are few studies of cardiovascular benefits of interruption
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br AR expression in breast tissue Although androgenic signal
2024-07-26
AR expression in breast tissue Although androgenic signalling is chiefly associated with the development and maintenance of primary and secondary male characteristics, especially during puberty when the testes are by far the major source of testosterone, the AR also plays important functions in f
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The current study was designed
2024-07-26
The current study was designed to investigate the effects of the 12/15-LOX inhibitor, LOXBlock-1 (LB1) in mice using a FeCl3-induced distal MCAO model, and to test its utility in conjunction with subsequent thrombolysis with tPA, which is to date the only FDA-approved drug for acute stroke treatment
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In order to get a better understanding
2024-07-26
In order to get a better understanding of this synergy, we tested the effect of preliminary incubation of LDN193189 with non-stimulating concentrations of gonadotropins or FSK before subsequent stimulation by FSK or gonadotropins alone, also at sub-stimulating concentrations. We observed that human
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The pathogenesis of d penicillamine induced
2024-07-25
The pathogenesis of d-penicillamine-induced MG is not clear. The repertoire of anti-AChR Pifithrin-μ synthesis in d-penicillamine-induced MG has been shown to be similar to that in idiopathic MG in terms of AChR antigenic regions, suggesting a common immune mechanism (Tzartos et al., 1988). About
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A correlation analysis was performed to investigate
2024-07-25
A correlation analysis was performed to investigate a possible relationship between serum resistin levels and MG-ADL. We observed a significant relationship between serum resistin levels and MG-ADL scores in AChR-GMG-positive cases (r=0.285, p=0.032; Fig. 1C). There were also significant correlation
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br Materials and methods br Results br Discussion The brain
2024-07-25
Materials and methods Results Discussion The brain is endowed with the 5-LOX enzymatic system (Lammers et al., 1996, Lindgren et al., 1984), but its physiological and pathological roles are still not clear. Inflammation is a characteristic of many neurodegenerative diseases such as Alzheime
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The structure of LO is divided in
2024-07-25
The structure of 5-LO is divided in two domains, the catalytic C-terminal domain and the N-terminal regulatory C2-like domain (C2ld) [59,60]. The C2ld spans the dorsomorphin 1-114 and is responsible for translocation and binding of calcium and membranes [61–63]. The catalytic domain is primarily an
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Introduction hydroxytryptamine HT is found throughout the bo
2024-07-25
Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary cyproheptadine hcl (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The current c